Shadow Posted June 15, 2024 Report Posted June 15, 2024 https://www.nature.com/articles/s41598-024-60858-1 From the paper: "It has been shown that KCC2 is regulated by 5-hydroxytriptamine (5-HT) type 2A receptors to serotonin79. This regulatory mechanism may account, at least in part, for the link between the serotoninergic system and tinnitus and/or hyperacusis76,80. Finally, KCC2 downregulation and chloride dysregulation offer new avenues of understanding the potential link between auditory symptoms (tinnitus and/or hyperacusis) and neurological and psychiatric diseases such as autism spectrum disorder21,81. Indeed, it has been suggested that autism spectrum disorder may be associated to chloride dysregulation25. Since KCC2 seems to play a strong role in neural hyperactivity after hearing loss, KCC2 enhancer may represent a promising pharmacotherapeutic target for treating tinnitus and/or hyperacusis." Serotonin messes up with chloride homeostasis. Solution: https://axonis.us/target-biology-kcc2/ " Fine-tuning chloride homeostasis in CNS neurons will enable them to respond to physiological GABA-mediated inhibition, without a need for global depressive effects on the brain (e.g., benzodiazepines). Therefore, AXN-027 offers a novel therapeutic approach for refractory epilepsy and pain, with improved tolerability and without debilitating side effects." Benzos help with both tinnitus and vss. This drug (AXN-027) should also help with VSS, notice I said should, w need this drug tested both for tinnitus and visual snow.
Shadow Posted July 6, 2024 Author Report Posted July 6, 2024 https://ovidrx.com/our-science/programs/ov350/ There's also this. I believe these drugs should work. I want to hear the opinions of others.
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